Modulating ANS with NanoVi®
The autonomic nervous system (ANS) regulates involuntary bodily functions such as heart rate, digestion, and respiratory patterns through its two main branches: the sympathetic nervous system (SNS), which drives the “fight or flight” response, and the parasympathetic nervous system (PNS), which promotes “rest and digest” activities. Achieving balance between these systems is vital for health, and the NanoVi® offers a unique approach to ANS modulation by addressing oxidative stress and supporting cellular repair.
Understanding the NanoVi® Device
Developed by Eng3 Corporation, the NanoVi® device is a non-invasive technology designed to enhance cellular health by reducing oxidative stress and aiding protein function. Unlike traditional vagus nerve stimulation (VNS) devices, which directly stimulate the vagus nerve, NanoVi® uses a patented bio-identical signaling approach. It generates a specific electromagnetic signal, matching the wavelength produced by the body’s “good” reactive oxygen species (ROS) during cellular repair, and delivers it via humidified air inhaled through a nasal cannula [1,]. This signal supports protein folding and cellular repair, indirectly influencing ANS balance by reducing oxidative stress and enhancing cellular vitality.
Mechanisms of NanoVi® in ANS Modulation
NanoVi® modulates the ANS by improving cellular health and reducing oxidative stress, which can disrupt autonomic balance. The key mechanisms include:
- Bio-Identical Signaling for Cellular Repair: NanoVi® produces a precise electromagnetic signal that mimics the body’s natural ROS signal for initiating cellular repair. This signal is absorbed by water droplets in humidified air, influencing the water surrounding proteins to promote proper folding and function [1,]. By enhancing cellular repair, NanoVi® reduces oxidative stress, which is linked to sympathetic overactivity [2].
- Enhancing Parasympathetic Activity: Studies and user reports indicate that NanoVi® sessions improve heart rate variability (HRV), a key marker of ANS balance, by increasing parasympathetic activity. For example, a study showed a 25% improvement in parasympathetic activity after a single NanoVi® session in adults with an average age of 61 [3,]. This suggests NanoVi® promotes a “rest and digest” state, counteracting stress-induced sympathetic dominance.
- Reducing Sympathetic Overdrive: Oxidative stress, caused by excessive free radicals, can exacerbate SNS activity, leading to conditions like hypertension or anxiety. By accelerating repair of oxidative damage, NanoVi® helps reduce sympathetic overdrive, as evidenced by a 37% reduction in stress index in HRV studies [3,].
- Supporting Protein Stability and Cellular Health: NanoVi® enhances protein stability, which is critical for cellular functions regulated by the ANS, such as cardiac and gastrointestinal activity. Research published in the International Journal of Molecular Sciences showed NanoVi® restored 42–45% of peroxidase activity in oxidized proteins, compared to 11% in controls, indicating significant cellular repair [4,].
- Indirect Vagal Influence: While NanoVi® does not directly stimulate the vagus nerve, its reduction of oxidative stress and improvement in cellular energy may enhance vagal tone indirectly. Improved cellular health supports neural signaling, potentially strengthening vagal pathways involved in PNS regulation [5].
Potential Applications of NanoVi® for ANS Modulation
NanoVi®’s ability to modulate the ANS through cellular repair and oxidative stress reduction has wide-ranging applications:
- Stress and Anxiety Management: By boosting parasympathetic activity and reducing oxidative stress, NanoVi® can alleviate symptoms of stress and anxiety. Users report improved sleep and reduced fatigue, which are linked to enhanced PNS function [6,].
- Cardiovascular Health: Improved HRV and reduced sympathetic activity may lower risks of hypertension and arrhythmias. A study showed a 14% reduction in oxidative stress markers after NanoVi® use, supporting cardiovascular health [3,].
- Digestive Health: Enhanced vagal tone may improve gastrointestinal motility, potentially benefiting conditions like irritable bowel syndrome (IBS) [7].
- Athletic Performance and Recovery: NanoVi® reduces post-exertion lactate by 17% and improves immune response markers by 10–17%, aiding faster recovery and reducing SNS-driven fatigue [3,].
- Anti-Aging and Chronic Disease Management: By repairing oxidative damage and supporting cellular health, NanoVi® may slow aging and aid in managing chronic conditions linked to ANS dysregulation [9,].
NanoVi® offers a unique, non-invasive approach to modulating the ANS by reducing oxidative stress and supporting cellular repair through bio-identical signaling. Its ability to enhance parasympathetic activity, reduce sympathetic overdrive, and improve HRV makes it a promising tool for stress management, cardiovascular health, athletic recovery, anti-aging and recovery from chronic disease.
References
- Eng3 Corporation. (2022). How does NanoVi® work? Oxidative Stress Relief | Repair Cell Damage with NanoVi. Retrieved from eng3corp.com
- Porges, S. W. (2007). The polyvagal perspective. Biological Psychology, 74(2), 116–143.
- Eng3 Corporation. (2021). NanoVi® Technology: Overview of Research Results. Oxidative Stress Relief | Repair Cell Damage with NanoVi. Retrieved from eng3corp.com
- Eng3 Corporation. (2022). Study Results Verify the Protective and Restorative Effects of NanoVi® on Damaged Proteins. International Journal of Molecular Sciences. Retrieved from eng3corp.com
- Tracey, K. J. (2002). The inflammatory reflex. Nature, 420(6917), 853–859.
- Troia, B. (2024). Using NanoVi to Lower Oxidative Stress, Improve Body Composition, and Boost Mitochondria. Quantified Bob. Retrieved from quantifiedbob.com
- Bonaz, B., et al. (2016). Chronic vagus nerve stimulation in Crohn’s disease: A 6-month follow-up pilot study. Neurogastroenterology & Motility, 28(6), 948–953.
- GeekWire. (2019). Athletes and biohackers embrace ‘structured water vapor’ recovery device from Seattle startup. Retrieved from geekwire.com
- Gates, D. (2025). NanoVi initiates skin strengthening at the cellular level. nanovi.de. Retrieved from nanovi.de
- Eng3 Corporation. (2022). Introduction to The NanoVi®. Oxidative Stress Relief | Repair Cell Damage with NanoVi. Retrieved from eng3corp.com
- Eng3 Corporation. (2019). Device Locator. Oxidative Stress Relief | Repair Cell Damage with NanoVi. Retrieved from eng3corp.com